The Shortest but Powerful dua - Allahumma inni as’aluka al-‘afiyah

 ALLAHUMMA INNI AS'ALUKA AL'AFIYAH.
 اللَّهُمَّ إِنِّي أَسْأَلُكَ الْعَافِيَةَ
O Allah, I ask You for well-being (health, safety, and protection)

Al-Abbas (R.A.), the Uncle of the Prophet Muhammad ﷺ, came to the Prophet Muhammad ﷺ and said: “Ya Rasulullah, teach me a Dua.”

The Prophet Muhammad ﷺ said: “O my Uncle, say:

اللَّهُمَّ إِنِّي أَسْأَلُكَ الْعَافِيَةَ

"ALLAHUMMA INNI AS' ALUKA AL'AFIYAH"

Meaning: "O Allah, I ask you for Afiyah." Now, what is Afiyah?
Afiyah means:

1. To be saved from any afflictions, you are in Afiyah.
2. To be healthy, you are in Afiyah.
3. To have enough money, you are in Afiyah.
4. To live, you are in Afiyah.
5. To have your children protected, you are in Afiyah.
6. And if you are forgiven and not punished, you are in Afiyah.
7. So basically, Afiyah means: “O Allah, protect me from any Pains and Sufferings.” This includes both Dunya and Akhirah.

Al-Abbas (R.A.) thought about this for a while, and then he came back after a few days and said (paraphrased): “Ya Rasulullah ﷺ, this Dua seems a little short. I want something big.” The Prophet Muhammad ﷺ said: “My Dear Uncle, ask Allah for Afiyah for Wallahi, you cannot be given anything better than Afiyah.” It is a simple Dua, Sincerely mean what you say while praying. “O Allah, I ask You to be saved from any Distress, Grief, Hardship, Harm, and don't test me, etc.” All of the above and much more are included in:

اللَّهُمَّ إِنِّي أَسْأَلُكَ الْعَافِيَةَ "ALLAHUMMA INNI AS' ALUKA AL'AFIYAH"
(Riyadh As Saliheen, Sunan At-Tirmidhi).